In newborns, vaccines respond differently depending on whether the birth was natural or cesarean.

In newborns, vaccines respond differently depending on whether the birth was natural or cesarean.

That microbiota gut (the sum of all microorganisms living in the human intestinal tract) proves again and again its influence on our health. Not only in infancy, but also since pregnancywhen the mother’s diet can tip the scales positively.

The gut microbiome is set at birth and develops rapidly in the first months of life under the influence of the mode of delivery, lactation and other factors such as antibiotic administration and nutrition. Timely exposure to certain microbes also shapes the immune system.

but Immune system needs to be helped with vaccines, a protection measured by a combination of innate and cellular immunity. The problem is that there are large individual differences in the response to vaccinations due to atrial fibrillationActors like genetics, sex, perinatal characteristics such as gestational age, birth weight, maternal antibodies and type of diet. And now a new determining factor is added: the intestinal microbiota, the sum of all microorganisms that are in the human intestinal tract up to the time of vaccination, also plays a role in immune responses. This offers an interesting target for Improving the effect of children’s vaccines.

Since this is a relatively new finding, the temporal relationship between the early contact with certain microbesthe composition of the gut microbiota and subsequent responses to childhood vaccinations.


Newborn

newborn baby | Pixabay

now a new one to learn, published in ‘Nature’, focuses precisely on this connection. A team led by Debby Bogaert from the University of Edinburgh investigated this Connection between delivery methodthe development of the gut microbiota in the first year of life and antibody responses to vaccination Pneumococcal vaccination in 101 infants aged 12 months and against meningococcal vaccination in 66 infants aged 18 months.

That Birth by vaginal delivery is associated with increased antibody responses to both vaccines. The results of the study showed that antibody levels in babies born vaginally were 1.7 times higher than in those born by cesarean section. For example, among a large number of bacteria in the gut, particularly high levels of two, Bifidobacterium and E. coli, have been associated with a high antibody response to the vaccine It protects against lung infections. These results are key to developing strategies that configure a more adequate gut microbiota to respond to vaccine effects.

The results also showed that the Breastfeeding can be associated with antibody levels 3.5 times higher compared to infants born naturally with formula. This is because newborns acquire the Bifidobacterium and E.coli bacteria through natural birth and breast milk. supplies the sugar so that these bacteria can thrive. This knowledge also serves to adjust the formulas many newborns are fed and adapt vaccination schedules to the type of birth, the authors say.

“I find it particularly interesting that we have that identified several beneficial microbes as a link between the mode of administration and the responses to vaccines – points out Bogaert in a Notice – . In the future, we may be able to supplement these bacteria for infants who are delivered via cesarean section shortly after birth, for example through “stool transplants” from mother to baby or by using specially developed probiotics.”

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